I'm curious what your concern with ClickOnce is.
The application is prettymuch x-copy deployable but it keeps settings and cached files in your appdata directory. I'm not sure of anything significant that using MSI would benefit over ClickOnce.
The main reason for using ClickOnce is it provides a solution for application updates, which is especially important since Facebook tends to unexpectedly change their API behaviors. When Fishbowl is run and not deployed through ClickOnce the user won't
get automatic updates and the app may run with limited functionality as parts of the Facebook integration begin to fail. I'd rather not make it so people who don't care about whether it's installed through ClickOnce accidentally opt-out of the app updating
itself by installing it a different way.